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November 19, 2009AnesthesiologyOpen Access

Too Much of a Good Thing Is Wonderful

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Key result

This editorial highlights the limitations of small sample sizes in studying intraoperative hypotension and advocates for large, multicenter perioperative databases to evaluate anesthetic outcomes.

Design

Editorial

Authors

SKSachin KheterpalDWDerek T. WoodrumKTKevin K. Tremper

Discussion

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Overview

Small perioperative studies on hypotension remain underpowered; leaves open whether multicenter databases can guide safer anesthetic practice.

PICO

P
Population
Intraoperative hypotension and perioperative outcomes
E
Exposure / Comparator
Intraoperative hypotension

Highlights the critical need for large-scale, multicenter anesthesia information management systems to evaluate perioperative outcomes and comparative effectiveness.

Limitations

  • Small sample sizes combined with infrequent adverse events limit traditional research tools
  • Lack of standardized definition for intraoperative hypotension
  • Idiosyncratic documentation patterns and lack of standardized anesthesia records

Cite This Study

Kheterpal et al. (2009) conducted an editorial in Intraoperative hypotension and perioperative outcomes. Intraoperative hypotension was evaluated. This editorial highlights the limitations of small sample sizes in studying intraoperative hypotension and advocates for large, multicenter perioperative databases to evaluate anesthetic outcomes.

synapsesocial.com/papers/6a984045476dc9b054d7dfe0https://doi.org/10.1097/aln.0b013e3181c1496c
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