Key result
Primary antiphospholipid syndrome in a patient with a bicuspid aortic valve led to spontaneous thrombosis of the valve and ascending aorta, requiring mechanical valve replacement.
This case highlights a rare presentation of spontaneous thrombosis of a bicuspid aortic valve due to primary antiphospholipid syndrome, successfully managed with surgical intervention.
May warrant antiphospholipid testing in unexplained bicuspid aortic valve thrombosis; single case leaves open broader screening or management recommendations.
We present the case of a 51-year-old man who was admitted as an emergency with spontaneous thrombosis of the aortic valve and ascending aorta. At operation he was found to have a congenitally bicuspid aortic valve and subsequent investigation revealed primary antiphospholipid syndrome. He underwent successful removal of the thrombus combined with mechanical replacement of the aortic valve.
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Farrell et al. (2010) studied this question. Primary antiphospholipid syndrome in a patient with a bicuspid aortic valve led to spontaneous thrombosis of the valve and ascending aorta, requiring mechanical valve replacement.
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