Key result
Calcific aortic valve disease accounts for 50% of cardiac valve disease, with approximately one third of the elderly having early valve disease and 2% developing symptomatic aortic stenosis by age 65.
C alcific aortic valve disease (CAVD), the progressive accumulation of fibrocalcific matrices and calcified, bony nodules in aortic valves that results in aortic stenosis, accounts for 50% of cardiac valve disease. In developed countries, CAVD is the third most common cardiovascular disease behind coronary artery disease and hypertension. lthough CAVD is often asymptomatic during the first several decades of life, notably, approximately one third of our elderly have early valve disease as indicated by echocardiographic or radiological evidence of aortic sclerosis. By age 65, 2% of individuals develop symptomatic aortic stenosis, characterized by severe valve calcification, impaired leaflet motion, and cardiac outflow, which, if untreated, leads to lifethreatening left ventricular dysfunction, angina, syncope, and heart failure.
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Giachelli et al. (2017) conducted a review in Calcific Aortic Valve Disease (CAVD). Calcific aortic valve disease accounts for 50% of cardiac valve disease, with approximately one third of the elderly having early valve disease and 2% developing symptomatic aortic stenosis by age 65.
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