Preparation of Organometallic Complexed Sugars: Hetero Diels−Alder Reactivity of Tricarbonyl(formyltrimethylenemethane)- iron

There has been considerable recent interest in the preparation of biologically important molecules which are "tagged" with a metal carbonyl group.Such compounds have been examined for use in carbonyl metallo immunoassays (CMIA) using FT-IR spectroscopy. 1 While the majority of these "tagged" molecules are within the steroidal family, the preparation of organometallic nucleotides, 2 leukotrienes, 3 and carbohydrates 4 have also been reported.σ-Bonded manganese and iron carbonyl complexes of carbohydrates have been prepared by displacement of 1-glucosyl halides or 6-deoxy-6-