Why the study?
Does switching from clozapine to risperidone reduce serum triglyceride levels in patients with psychotic disorders?
Does switching from clozapine to risperidone reduce serum triglyceride levels in patients with psychotic disorders?
Switching from clozapine to risperidone resolves clozapine-induced hypertriglyceridemia, highlighting the need for lipid monitoring in clozapine-treated patients with cardiac risk factors.
Answers are grounded in this paper and cite their sources.
May support lipid monitoring with clozapine; case report leaves open generalizability and cardiovascular benefit.
Serum triglyceride levels of four patients with psychotic disorders were decreased after switching therapy from clozapine to risperidone. In two patients clozapine was reinstated after risperidone was discontinued; serum triglyceride levels increased. This increase when clozapine was switched to risperidone and vice versa is consistent with our previous report of elevated serum triglyceride levels in clozapine-treated patients. Other reports show increases with the atypical antipsychotics, olanzapine and quetiapine. We believe serum triglyceride levels should be monitored in patients who have other cardiac risk factors and are receiving clozapine.
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Dufresne et al. (1999) studied this question.
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