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The replacement of the H atom in CCH by Br or I can be accomplished with N-bromo- and N-iodosuccinimide, respectively, in the presence of silver salt catalysts. This method could be used, inter alia, to prepare numerous 17α-bromo- 2 and 17α-iodoethynyl steroids 3. In contrast to older methods, the hydroxy- (and carbonyl-) groups in 1 do not have to be protected.
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Hofmeister et al. (1984) studied this question.
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