Key result
Each unit increase in the Apnea-Hypopnea Index score was associated with a 1.54-fold higher odds of cardiovascular events in obese patients with sleep apnea.
Why the study?
Sleep apnea and cardiovascular disease are prevalent among obese individuals, and understanding their relationship is crucial for effective management.
Cohort (n=81)
Yes
In obese patients with sleep apnea, increasing severity of sleep apnea (measured by AHI) is independently associated with a significantly higher risk of cardiovascular events.
AHI may aid CV risk stratification in obese OSA; leaves open whether AHI reduction improves outcomes.
Introduction: Sleep apnea and cardiovascular disease (CVD) are prevalent among obese individuals, posing significant health risks globally. Understanding their relationship is crucial for effective management. Methodology: Data from 81 obese individuals with identified sleep apnea at Pakistan Institute of Medical Sciences (PIMS) in Islamabad from June 2021 to May 2024 were examined in this retroactive cohort research. Using logistic regression, demographic information, sleep apnea degree (Apnea-Hypopnea Index, AHI), cardiovascular risk factors, and outcomes were examined. Results: The study revealed a high frequency (67%), of moderate to severe OSA (AHI >15). Common comorbidies were hypertension (58%), diabetes mellitus (42%), and coronary artery disease (27%). A 1.54-fold higher chances of cardiovascular events (p < 0.001) with per unit rise in AHI score. Conclusion: In obese people, the degree of sleep apnea strongly corresponds with cardiovascular risk. Reducing these hazards depends on integrated management plans. New therapy strategies should be investigated in future studies and results validated among several populations.
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Rashid et al. (2024) conducted a cohort in Obesity and sleep apnea (n=81). Sleep apnea severity (Apnea-Hypopnea Index) vs. Lower Apnea-Hypopnea Index was evaluated on Cardiovascular events (OR 1.54, 95% CI 1.23-1.92, p=<0.001). Each unit increase in the Apnea-Hypopnea Index score was associated with a 1.54-fold higher odds of cardiovascular events in obese patients with sleep apnea.
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