Key result
In patients with obstructive sleep apnea, cardiovascular risk was weakly correlated with BMI (r = 0.33; P < 0.001) and strictly related to obesity (P < 0.00002), but did not vary with AHI.
Why the study?
Obstructive sleep apnea promotes endothelial dysfunction and contributes to extended cardiovascular risk, prompting evaluation of cardiovascular risk in OSA patients.
Observational
Effect estimate: r = 0.33
p-value: p=< .001
In OSA patients, cardiovascular risk appears to be driven more by obesity and BMI than by the severity of apnea-hypopnea index (AHI).
BACKGROUND: Obstructive sleep apnea (OSA) is a worldwide increasing syndrome, which, by promoting endothelial dysfunction, contributes to extend the cardiovascular risk. We evaluated the cardiovascular risk in a group of OSA patients. METHODS: defined as normal weight subjects (Group 3 n = 19, mean age 54.2 ± 2.3; 64,2% men). RESULTS: In the whole population, the percentage cardiovascular risk was weakly related with BMI (r = 0.33; P < .001), but not with AHI. The cardiovascular risk was strictly related to the obesity (P < .00002), while the Epworth Questionnaire score and the Charlson Co-morbidity Index were respectively statistically higher in the group of obese individuals (P = .004, P = .0002) than in the other two sub-groups. When AHI values were stratified in tertiles, the percentage cardiovascular risk did not vary with increasing AHI values (Figure 2). CONCLUSIONS: Further studies are required to investigate the pivotal role of inflammation resulting from obesity, and underlying increased cardiovascular risk in OSA patients.
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Carratù et al. (2021) conducted an observational in Obstructive Sleep Apnea Syndrome. Body mass index and obesity vs. Normal weight was evaluated on Percentage cardiovascular risk (r = 0.33, p=< .001). In patients with obstructive sleep apnea, cardiovascular risk was weakly correlated with BMI (r = 0.33; P < 0.001) and strictly related to obesity (P < 0.00002), but did not vary with AHI.
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