Key result
The KCNQ1 gene promoter variant c.1-182C>T was significantly more frequent in ventricular fibrillation survivors with coronary artery disease compared to controls without malignant arrhythmias (OR 2.57).
Why the study?
Are promoter variants in ion channel genes more frequent in CAD patients who survive ventricular fibrillation compared to controls?
Case-Control (n=186)
No
Are promoter variants in ion channel genes more frequent in CAD patients who survive ventricular fibrillation compared to controls?
Odds Ratio: 2.57 (95% CI 1.18–5.57)
Absolute Event Rate: 82.3% vs 64.3%
p-value: p=0.008
Promoter variants in ion channel genes are common in both VF survivors and controls, suggesting they are geographically specific rather than a common cause of sudden cardiac death.
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Novotný et al. (2013) conducted a case-control in Ventricular fibrillation in coronary artery disease (n=186). Ion channel gene promoter variants (e.g., KCNQ1 c.1-182C>T) vs. CAD patients without malignant arrhythmias was evaluated on Allelic frequency of KCNQ1 c.1-182C>T variant (OR 2.57, 95% CI 1.18-5.57, p=0.008). The KCNQ1 gene promoter variant c.1-182C>T was significantly more frequent in ventricular fibrillation survivors with coronary artery disease compared to controls without malignant arrhythmias (OR 2.57).
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