Key result
Prior chest radiation therapy in cancer survivors undergoing transcatheter aortic valve replacement was associated with a significantly higher 1-year mortality (OR 1.97) compared to patients without prior radiation.
Why the study?
Cancer survivors with prior chest radiation therapy and aortic stenosis are high risk for surgical valve replacement, but TAVR outcomes in this population are not well established in major clinical trials.
Population
2054 patients undergoing TAVR (164 with and 1890 without prior chest radiation therapy)
Comparison
Prior chest radiation therapy vs no prior chest radiation therapy
Design
Systematic review and meta-analysis of four studies
Follow-up
30-day and 1-year follow-ups
Authors
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May warrant caution in TAVR candidates with prior radiation; leaves open need for prospective validation and adjusted risk models.
Meta-Analysis (n=2,054)
Odds Ratio: 1.97 (95% CI 1.15–3.39)
p-value: p=0.01
Zafar et al. (2020) conducted a meta-analysis in Severe aortic stenosis in cancer survivors (n=2,054). Prior chest radiation therapy (C-XRT) vs. Patients with severe aortic stenosis without prior chest radiation therapy was evaluated on All-cause mortality at 1-year follow-up (OR 1.97, 95% CI 1.15 to 3.39, p=0.01). Prior chest radiation therapy in cancer survivors undergoing transcatheter aortic valve replacement was associated with a significantly higher 1-year mortality (OR 1.97) compared to patients without prior radiation.
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