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More stress from hospitalization, measured by level of anxiety at time of admission, in 75 males without cancer, infection, or autoimmune disease was associated with depressed immunological response of lymphocytes in vitro but positive reactions to skin tests of more delayed hypersensitivity. Findings suggest that psychological states of perceived stress and anxiety influence functioning of the immune system and could lead to greater vulnerability to infections and disease.
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Linn et al. (1981) studied this question.
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