Synthesis, Fungicidal and Antibacterial Activity of New Pyridazine Derivatives

Compounds 1 -3 were obtained in the reaction of 3,6-dichloropyridazines with phenylacetonitriles in the biphasic system -DMSO / 50% NaOH.The chlorine atom was replaced with cycloalkylamino (4 -13) and hydrazinyl (23, 24) moiety.These last compounds were condensed with aldehydes (25 -34).Pyridazynylphenylacetonitriles were converted into amides 14 -18 and thioamides 19 -22.In compounds 2, 3 the chlorine atom was replaced with thiophenyl (37, 38) and in compound 1 with thioethyl and thiophenyl (35, 36) functional groups.In the reactions of compounds 1, 2 with ammonium polysulfide thioamides with thiol group (39, 40) and chlorine atom (41, 42) were obtained.Compounds 1 -17, 19 -43 were screened for antibacterial and fungicidal activities.