Why the study?
Recent studies indicated that hospitalized COVID-19 patients have an increased incidence of arrhythmia, particularly atrial fibrillation.
Does new-onset atrial fibrillation predict intrahospital mortality in hospitalized COVID-19 patients?
Observational (n=383)
No
Does new-onset atrial fibrillation predict intrahospital mortality in hospitalized COVID-19 patients?
New-onset atrial fibrillation is a significant predictor of intrahospital mortality and need for intensive care in hospitalized COVID-19 patients.
New-onset AF may identify hospitalized COVID-19 patients needing closer monitoring; hypothesis-generating and requires confirmation in prospective studies.
Recent studies show that hospitalized COVID-19 patients have an increased incidence of arrhythmia, especially atrial fibrillation (AF). This single-center study included 383 hospitalized patients with positive polymerase chain reaction tests for COVID-19 from March 2020 to April 2021. Patient characteristics were documented, and data were analyzed for episodes of AF on admission or during the hospital stay, intrahospital mortality, need for intensive care and/or invasive ventilation, inflammatory parameters (hs-CRP, IL-6, and procalcitonin), and differential blood count. We demonstrated that in the setting of hospitalized cases of COVID-19 infection, there is an incidence of 9.8% (n = 36) for the occurrence of new-onset AF. Furthermore, it was shown that a total of 21% (n = 77) had a history of episodes of paroxysmal/persistent AF. However, only about one-third of patients with pre-existing AF had relevant documented tachycardic episodes during the hospital stay. Patients with new-onset AF had a significantly increased intrahospital mortality compared to the control and the pre-existing AF without rapid ventricular rate (RVR) group. Patients with new-onset AF required intensive care and invasive ventilation more frequently. Further analysis examined patients with episodes of RVR and demonstrated that they had significantly elevated CRP (p < 0.05) and PCT (p < 0.05) levels on the day of hospital admission compared to patients without RVR.
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Parahuleva et al. (2023) conducted an observational in COVID-19 (n=383). New-onset atrial fibrillation vs. Control and pre-existing AF without rapid ventricular rate was evaluated on Intrahospital mortality.
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