Key result
A preoperative plasma level of TAZ ≥ 12.70 ng/mL was associated with a significantly higher risk of postoperative in-hospital mortality in patients with acute type A aortic dissection (OR 10.08).
Why the study?
Surgical repair of acute type A aortic dissection has high risk and mortality, but few biomarkers of postoperative in-hospital mortality exist.
Does a high preoperative plasma level of TAZ predict postoperative in-hospital mortality in patients with acute type A aortic dissection?
Cohort (n=95)
No
Does a high preoperative plasma level of TAZ predict postoperative in-hospital mortality in patients with acute type A aortic dissection?
Elevated preoperative plasma TAZ levels (≥12.7 ng/mL) are strongly associated with increased postoperative in-hospital mortality in patients undergoing surgical repair for acute type A aortic dissection.
May aid preoperative risk stratification in acute type A aortic dissection; hypothesis-generating and requires prospective validation.
Background: Surgical repair of Acute type A aortic dissection (ATAAD) has high risk and mortality, and there is few biomarker of postoperative in-hospital mortality until now. This study investigated the association between WW domain–containing transcription regulator protein 1(TAZ) and the postoperative in-hospital mortality of ATAAD patients. Methods: This is a retrospective cohort study. Data and blood samples were collected from 95 consecutive patients with ATAAD who underwent surgeries in our hospital from July 1, 2016, to December 31, 2016. The data collection included all the risk factors introduced by the modified EuroSCORE (European System for Cardiac Operative Risk Evaluation). The predictors of postoperative in-hospital death were confirmed by univariate regression analysis. Multivariable logistic regressions were used to analyze the association of the preoperative plasma level of TAZ and the postoperative in-hospital mortality of ATAAD patients. In addition, we used the generalized additive model to identify nonlinear relationships. Results: Three models were used in the multivariable logistic regression analysis of the relationship between the preoperative plasma level of TAZ and postoperative in-hospital death. In the crude model, the preoperative plasma level of TAZ showed a positive correlation with postoperative in-hospital death [odds ratio (OR)=1.33, 95% confidence interval (CI): 1.01 to 1.74, P=0.039]. In adjusted model I and adjusted model II, similar results were found (OR=1.35, 95% CI: 1.01 to 1.80, P=0.043 and OR=1.35, 95% CI: 1.01 to 1.81, P=0.039). The risk of postoperative in-hospital death in the preoperative plasma level of TAZ ≥12.7 ng/mL group was 10.08 times (OR=10.08, 95% 1.63 to 62.37; P=0.013) that of the preoperative plasma level of TAZ<12.7 ng/mL group. Conclusions: The high preoperative plasma level of TAZ suggested poor surgical prognosis for ATAAD patients. The patients with a preoperative plasma level of TAZ ≥12.7 ng/ml had much higher postoperative in-hospital mortality.
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Jiang et al. (2020) conducted a cohort in Acute Type A Aortic Dissection (n=95). Preoperative plasma level of TAZ ≥ 12.70 ng/mL vs. Preoperative plasma level of TAZ < 12.70 ng/mL was evaluated on Postoperative in-hospital mortality (OR 10.08, 95% CI 1.63-62.37, p=0.01). A preoperative plasma level of TAZ ≥ 12.70 ng/mL was associated with a significantly higher risk of postoperative in-hospital mortality in patients with acute type A aortic dissection (OR 10.08).
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