Effect of 5-Iodo-2′-Deoxyuridine on the Pathogenesis of Columbia-SK Virus in Mice

This is the authors' abstract. We don't add key points for this paper.

Summary 5-Iodo-2′-deoxyuridine (IUDR) at 150 and 75 mg/kg, administered subcutaneously 1 hr before and 1, 24 and 28 hr after infection, significantly (P = < 0.01) protected mice infected intraperitoneally with 5 LD50 but not greater doses of Columbia-SK virus. IUDR did not appear to inhibit virus multiplication in the brain. The 48-hr delay in virus infiltration of the brain of mice treated with IUDR (150 mg/kg) is believed to play a role in protection. The absence of detectable virus in the leukocytes during the first 48 hr of infection might account for the delay. Experimental attempts to define the relationship of the circulating leukocyte to protection are discussed.