Key result
Inactivation of Tgfbr2 in endothelial cells resulted in deficient ventricular septation and cerebral blood vessel haemorrhage, demonstrating its essential role in cardiac development.
TGFβ signalling through the Tgfbr2 receptor in endothelial cells is critical for normal cardiac development and cerebral vascular integrity.
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Does not inform practice; leaves open whether endothelial Tgfbr2 is required for human cardiac septation and cerebral vascular integrity.
Robson et al. (2010) studied Cardiac development. Depletion of Tgfbr2 in endothelial cells vs. Other regional knockouts or wild-type was evaluated on Cardiac phenotype and vascular integrity. Inactivation of Tgfbr2 in endothelial cells resulted in deficient ventricular septation and cerebral blood vessel haemorrhage, demonstrating its essential role in cardiac development.
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