Key result
Dexmedetomidine altered the cardiovascular response during aortic surgery in sevoflurane-anesthetized dogs, lowering cardiac index and heart rate while increasing mean arterial pressure.
Why the study?
Does dexmedetomidine alter hemodynamics and systemic oxygenation during infra-renal aortic cross-clamping in sevoflurane-anesthetized dogs?
Population
20 dogs anesthetized with sevoflurane undergoing infra-renal aortic cross-clamping (Aox) and unclamping (UAox)
Comparison
Dexmedetomidine vs Saline infusion only
Design
Preclinical, randomly assigned
Follow-up
40 min after aortic unclamping
Authors
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Should not change human practice; hypothesis-generating for dexmedetomidine hemodynamics during aortic cross-clamping under sevoflurane.
RCT (n=20)
Does dexmedetomidine alter hemodynamics and systemic oxygenation during infra-renal aortic cross-clamping in sevoflurane-anesthetized dogs?
In a canine model, dexmedetomidine significantly alters the cardiovascular response during aortic cross-clamping under sevoflurane anesthesia, leading to greater increases in vascular resistance and decreases in cardiac index.
Braz et al. (2008) conducted an RCT in aortic surgery (n=20). Dexmedetomidine vs. saline infusion was evaluated on Hemodynamics and systemic oxygenation. Dexmedetomidine altered the cardiovascular response during aortic surgery in sevoflurane-anesthetized dogs, lowering cardiac index and heart rate while increasing mean arterial pressure.
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