Key result
Gene expression profiling of non-calcified controls, sclerotic, and calcified aortic valves was performed and deposited in the GEO database (GSE51472).
Provides a publicly available gene expression microarray dataset to study the progression of human calcific aortic valve disease.
Calcific aortic valve disease is a slowly progressive disorder that ranges from mild valve thickening (i.e. aortic sclerosis) to severe calcification of valves (i.e. aortic stenosis). Gene expression profiling analysis of non-calcified controls, sclerotic, and calcified aortic valves was performed to better understand the progression of calcific aortic valve disease. The complementary information related to processing and statistical analysis of the DNA microarray data is provided in this article. Interpretation of this data can be found in a research article entitled "MicroRNA-125b and chemokine CCL4 expression are associated with calcific aortic valve disease" [1]. The microarray data complies with MIAME guidelines and is deposited in the Gene Expression Omnibus (GEO) database under accession number GSE51472.
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Jaana Rysä (2015) studied Calcific aortic valve disease. Sclerotic and calcified aortic valves vs. Non-calcified controls was evaluated on Gene expression profiles. Gene expression profiling of non-calcified controls, sclerotic, and calcified aortic valves was performed and deposited in the GEO database (GSE51472).
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