Oxidative Mizoroki–Heck‐Type Reaction of Arylsulfonyl Hydrazides for a Highly Regio‐ and Stereoselective Synthesis of Polysubstituted Alkenes

A useful source: Arylsulfonyl hydrazides have been identified as synthetically useful aryl sources for the Pd(OAc)2 catalyzed oxidative Mizoroki–Heck-type reaction under molecular oxygen to provide a convenient access to polysubstituted alkenes in a highly regio- and stereoselective manner (see scheme). The reaction well tolerates various functional groups such as alkoxy, halo, alcohol, carboxylic acid, ester, amide, sulfonamide, and sulfone.