Rationale: Favism is a genetic disease of Glucose 6 phosphatase dehydrogenase (G6PD) deficiency in human red blood cells. It is mainly due to the mutation of G6PD gene encoded on the X chromosome, which leads to the decrease of G6PD activity or deficiency. G6PD plays important roles in the metabolic process of human body. One of them is to protect the integrity of the erythrocyte membrane. When the body is lack of G6PD or its activity is reduced, the patient is prone to hemolysis after eating oxidant, such as fresh broad bean, or under strong stress.
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Wang et al. (2018) studied this question.
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