Key result
Chemically inducible artificial transcription factors using FKBP-rapamycin-FRB and GAI-gibberellin-GID systems successfully enabled orthogonal and time-dependent regulation of multiple genes.
Population
In vitro models for reporter gene assays and endogenous gene activation
Design
Preclinical
Authors
Loading...
May advance preclinical gene regulation tools; leaves open translation to cardiovascular research or therapy.
Chemically inducible artificial transcription factors can provide time-dependent, orthogonal regulation of multiple genes.
Nomura et al. (2018) studied this question. Chemically inducible artificial transcription factors (FKBP-rapamycin-FRB and GAI-gibberellin-GID systems) was evaluated on Gene expression regulation (reporter gene assays and endogenous genes). Chemically inducible artificial transcription factors using FKBP-rapamycin-FRB and GAI-gibberellin-GID systems successfully enabled orthogonal and time-dependent regulation of multiple genes.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: