Key result
A computer-based electronic alert system improved adequate oral anticoagulant prescription at hospital discharge compared to standard care (22.0% vs 15.9%; RR 1.38; P=0.021).
Why the study?
Does a computer-based electronic alert system improve adequate OAC prescription in hospitalized OAC-naïve patients with atrial fibrillation?
RCT (n=889)
1:1
No
Does a computer-based electronic alert system improve adequate OAC prescription in hospitalized OAC-naïve patients with atrial fibrillation?
Relative Risk: 1.38
Absolute Event Rate: 22% vs 15.9%
p-value: p=0.021
An electronic alert system modestly improved the rate of adequate oral anticoagulant prescription at discharge for hospitalized OAC-naïve patients with atrial fibrillation.
Alerts warrant hospital implementation to raise OAC prescribing in AF inpatients; confirms randomized benefit of decision-support tools.
BACKGROUND: Many patients with atrial fibrillation (AF) do not receive oral anticoagulants (OAC) for the prevention of stroke and systemic embolism. We aimed to improve the prescription of (OAC) among hospitalized patients with AF. METHODS AND RESULTS: We developed a computer-based electronic alert system for identifying hospitalized OAC-naïve patients with AF. The alert system contained a CHA2DS2-VASc score calculation tool and provided recommendations for OAC prescription. The alert system was tested in a 1:1 randomized controlled trial at the University Hospital Bern: Patients with suspected AF without an active prescription order were allocated to an alert group in which an alert was issued in the electronic patient chart and order entry system or to a control group in which no alert was issued. The primary end point was the rate of adequate OAC prescription at hospital discharge, defined as prescription in OAC-naïve men and women with CHA2DS2-VASc score ≥1 and ≥2, respectively. Overall, 889 OAC-naïve patients (455 from the alert group and 434 from the control group) were eligible for analysis. Although the CHA2DS2-VASc score module was used in only 48 (10.5%) patients from the alert group, 100 (22.0%) patients from the alert group versus 69 (15.9%) from the control group received adequate OAC prescription (relative risk 1.38; P=0.021). OAC or antiplatelet therapy was prescribed in 325 (71.4%) patients from the alert group versus 271 (62.4%) from the control group (P=0.004). CONCLUSIONS: Versus standard care, the alert system modestly improved OAC prescription among consecutive hospitalized AF patients. CLINICAL TRIAL REGISTRATION: URL: https://www.clinicaltrials.gov. Unique identifier: NCT02455102.
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Silbernagel et al. (2016) conducted an RCT in Atrial Fibrillation (n=889). Computer-based electronic alert system vs. Standard care (no alert) was evaluated on Rate of adequate OAC prescription at hospital discharge (relative risk 1.38, p=0.021). A computer-based electronic alert system improved adequate oral anticoagulant prescription at hospital discharge compared to standard care (22.0% vs 15.9%; RR 1.38; P=0.021).