Key result
Blood serum levels of p46 Myo1C were high in patients with multiple sclerosis and rheumatoid arthritis, relatively low in systemic lupus erythematosus, and undetected in healthy donors.
Observational
The 46 kDa fragment of unconventional myosin 1c (p46 Myo1C) in blood serum may serve as a potential biomarker for autoimmune diseases such as MS and RA.
May support p46 Myo1C as an autoimmune biomarker; leaves open diagnostic utility pending prospective validation.
We searched for protein markers present in blood serum of multiple sclerosis (MS), rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) patients in comparison to healthy human individuals. We used precipitation/extraction methods and MALDI TOF/TOF mass spectrometry, and identified a protein with Mr ~46 kDa as a fragment of human unconventional myosin IC isoform b (Myo1C). Western blotting with specific anti-human Myo1C antibodies confirmed the identity. Screening of blood serum samples from different autoimmune patients for the presence of Myo1c revealed its high level in MS and RA patients, relatively low level in SLE patients, and undetected in healthy donors. These data are suggesting that the level of p46 Myo1C in blood serum is a potential marker for testing of autoimmune diseases.
No takes yet. Share an insight, caveat, or question.
Myronovkij et al. (2015) conducted an observational in Autoimmune diseases (multiple sclerosis, rheumatoid arthritis, systemic lupus erythematosus). Autoimmune diseases (MS, RA, SLE) vs. Healthy donors was evaluated on Presence and level of p46 Myo1C in blood serum. Blood serum levels of p46 Myo1C were high in patients with multiple sclerosis and rheumatoid arthritis, relatively low in systemic lupus erythematosus, and undetected in healthy donors.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: