Key result
Heart-specific autoantibodies against alpha- and beta-cardiac myosin heavy chain isoforms were detected in 86% of antibody-positive DCM patients versus 0% of normal subjects (p=0.0001).
Population
51 subjects including 26 patients with idiopathic dilated cardiomyopathy, 12 patients with cardiac failure…
Comparison
Western blotting of sera against crude… vs Sera from normal subjects and patients with…
Design
Case-control
Authors
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Supports myosin autoantibodies in DCM; leaves open diagnostic/therapeutic utility pending prospective studies.
Case-Control (n=51)
Absolute Event Rate: 86% vs 0%
p-value: p=0.0001
Alpha- and beta-cardiac myosin heavy chain isoforms are major autoantigens in patients with idiopathic dilated cardiomyopathy.
Caforio et al. (1992) conducted a case-control in Dilated cardiomyopathy (n=51). Sera testing for cardiac myosin autoantibodies vs. Normal subjects and patients with other cardiac failure was evaluated on Reactivity with alpha- and beta-cardiac myosin heavy chain isoforms (p=0.0001). Heart-specific autoantibodies against alpha- and beta-cardiac myosin heavy chain isoforms were detected in 86% of antibody-positive DCM patients versus 0% of normal subjects (p=0.0001).
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