Key result
Prenatal or postnatal administration of hydrogen sulfide significantly attenuated Angiotensin II-induced sympathetic excitation and elevated systolic blood pressure in offspring of hypertensive rats.
Why the study?
Parental health during pregnancy is associated with cardiovascular disease in offspring, but whether offspring of renovascular hypertensive animals have enhanced AngII sensitivity and whether H2S can attenuate this response was unknown.
Does hydrogen sulfide administration attenuate AngII-induced sympathetic excitation in offspring of renovascular hypertensive rats?
Does hydrogen sulfide administration attenuate AngII-induced sympathetic excitation in offspring of renovascular hypertensive rats?
p-value: p=<0.05
In a rat model, prenatal or postnatal administration of hydrogen sulfide attenuated AngII-induced sympathetic excitation and hypertension in the offspring of hypertensive mothers by modulating AT1R and ATRAP expression in the nucleus tractus solitarii.
Objective: Numerous findings have demonstrated a strong association between parental health during pregnancy and cardiovascular disease in adult offspring. This study investigated whether sensitivity to angiotensin II (AngⅡ) is enhanced in offspring of renovascular hypertensive animals and whether hydrogen sulfide (H2S) can attenuate the increased response to AngⅡ in offspring. Method: The systolic blood pressure (SBP) was measured by non-invasive tail-cuff plethysmograpy every two weeks in all offspring from 8 to 16 weeks. After intracerebroventricular microinjection of AngⅡin the offspring, blood pressure, heart rate and renal sympathetic nerve activity were recorded to test the response to Ang II in the offspring. Western blot analysis was used to examine the protein expression of AT1R, AT1R-associated protein (ATRAP), Nox2, p67phox, and nitrotyrosine in the nucleus tractus solitarii (NTS). Results: The SBP in the offspring of hypertensive rats were significantly higher than that in control group, and the above effects were significantly improved by prenatal or postnatal administration of H2S. Intralateroventricular microinjection of AngⅡinduced greater sympathetic responses in offspring of hypertensive rats than control group. The expression of AT1R and oxidative stress-related protein was increased, whereas that of ATRAP was decreased in the NTS in offspring of hypertensive rats. Exogenous administration of H2S prenatally or postnatally improved the above effects. Conclusion: Prenatal or postnatal administration of H2S attenuated AngII-induced sympathetic excitation in offspring of hypertensive rats, which may occur by modulating the balance between AT1R and ATRAP and downregulating oxidative stress-related protein expression in the NTS.
No takes yet. Share an insight, caveat, or question.
Feng et al. (2020) studied Renovascular hypertension. Hydrogen sulfide (NaHS) vs. No NaHS treatment was evaluated on Systolic blood pressure and sympathetic response to Ang II (p=<0.05). Prenatal or postnatal administration of hydrogen sulfide significantly attenuated Angiotensin II-induced sympathetic excitation and elevated systolic blood pressure in offspring of hypertensive rats.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: