Why the study?
What is the dose-response relationship of sublingual nitroglycerin on brachial artery diameter and augmentation indices in healthy men?
What is the dose-response relationship of sublingual nitroglycerin on brachial artery diameter and augmentation indices in healthy men?
Relatively low doses of sublingual nitroglycerin (8-50 μg) produce changes in brachial artery diameter and augmentation indices similar to endothelium-dependent stimuli, suggesting these doses are appropriate for differentiating endothelial from generalized vascular dysfunction.
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Low-dose sublingual NTG enables separate assessment of endothelium-independent vasodilation in FMD testing; extends standardization of vascular reactivity protocols.
Oliver et al. (2005) studied this question.
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