Key result
Olanzapine therapy was associated with extreme elevations in triglyceride levels in a male patient, requiring aggressive treatment to allow continued use of the medication.
Why the study?
Does olanzapine cause severe hypertriglyceridemia?
Does olanzapine cause severe hypertriglyceridemia?
Olanzapine can induce severe hypertriglyceridemia, which may be managed with aggressive lipid-lowering therapy to allow continued psychiatric treatment.
Alerts clinicians to monitor lipids on olanzapine; leaves open generalizability and optimal management beyond this single case.
We report on the case of a male patient who developed extreme elevations in triglyceride levels after the initiation of olanzapine, but has subsequently been maintained on olanzapine through aggressive treatment with agents to combat this adverse effect.
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Stoner et al. (2002) studied this question. Olanzapine therapy was associated with extreme elevations in triglyceride levels in a male patient, requiring aggressive treatment to allow continued use of the medication.
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