Why the study?
Does intravenous carbachol and pentagastrin affect gastric secretion of acid, pepsin, and intrinsic factor in healthy students?
Does intravenous carbachol and pentagastrin affect gastric secretion of acid, pepsin, and intrinsic factor in healthy students?
Carbachol stimulates gastric acid, pepsin, and intrinsic factor secretion independently of plasma gastrin changes, without potentiating pentagastrin effects.
Carbachol may stimulate gastric secretions independently of gastrin in healthy volunteers; leaves open relevance to acid-related disorders or therapy.
Vatn, M. H., Schrumpf, E. & Myren, J. The effect of carbachol and pentagastrin on the gastric secretion of acid, pepsin, and intrinsic factor (IF) in man. Scand. J. Gaslroenl. 1975, 10, 55-58.Intravenous infusions of carbachol and pentagastrin were given separately or simultaneously in 6 healthy students. The volume of gastric secretion and the concentration and output of acid, pepsin, and IF increased significantly during infusion of carbachol alone, whereas the plasma gastrin concentration remained unchanged. Carbachol had no effect on the acid, pepsin, and IF secretion stimulated by pentagastrin. The results indicate an effect of carba-chol on acid, pepsin, and IF secretion, independent of changes in plasma gastrin concentration. No synergistic or potentiating effect was demonstrated between carbachol and pentagastrin.
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Vatn et al. (1975) studied this question.
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