Population
Rat ventricular myocytes and rat papillary muscles
Comparison
Carbachol (300 mumol/l) vs Baseline, atropine, or varying extracellular…
Design
Preclinical
Follow-up
7-10 minutes
Authors
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Findings in rat myocytes should not inform clinical practice; leaves open muscarinic modulation of ventricular calcium in larger models.
Stimulation of muscarinic receptors with carbachol increases free intracellular calcium concentration in rat ventricular myocytes, an effect dependent on extracellular calcium and sodium.
Korth et al. (1988) studied this question.
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