Carbachol promotes Na/Ca exchange current at the sarcolemma via muscarinic receptors through a mechanism requiring the sarcoplasmic reticulum, which accounts for increased contractions in guinea pig ventricular myocytes.
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Findings in guinea pig myocytes warrant no clinical changes; leaves open muscarinic effects on Na/Ca exchange in human cardiomyocytes.
Saeki et al. (1997) studied this question.
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