What question did this study set out to answer?

To assess the intestinal expression, cellular localization, and cytokine correlations of the anti-inflammatory cytokine IL-37 in children with chronic inflammatory bowel disease.

April 11, 2014Journal of Pediatric Gastroenterology and Nutrition

Intestinal Expression of the Anti‐Inflammatory Interleukin‐1 Homologue IL‐37 in Pediatric Inflammatory Bowel Disease

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Authors

SWSimon WeidlichTumkur University ABAna‐Maria BulauLudwig-Maximilians-Universität München TSTobias SchwerdLMU Klinikum

Discussion

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Implication

Observational study reveals epithelial and lymphoid IL-37 expression correlates with inflammation severity in pediatric IBD, suggesting a regulatory role in chronic gut inflammation.

Key Points

To assess the intestinal expression, cellular localization, and cytokine correlations of the anti-inflammatory cytokine IL-37 in children with chronic inflammatory bowel disease.
Obtained endoscopic intestinal biopsies from pediatric participants, comprising 18 patients with Crohn disease, 14 with ulcerative colitis, and 11 healthy controls.
Evaluated IL-37 protein and mRNA expression via immunohistochemistry and real-time polymerase chain reaction, correlating findings with histological inflammation severity, clinical parameters, and levels of IL-18, IL-17, IL-8, and IL-10.
IL-37 protein localized to intestinal epithelial cells and submucosal lymphoid cells in healthy controls and IBD patients, with higher lymphoid expression positively correlating with histological inflammation severity scores.
Messenger RNA levels of IL-8, IL-17, and IL-10 were significantly elevated in Crohn disease and ulcerative colitis, whereas IL-37 and IL-18 mRNA levels were not significantly elevated compared to controls but showed a positive correlation with each other in Crohn disease.

Cite This Study

Weidlich et al. (2014) studied this question.

synapsesocial.com/papers/6a9864e604c78a31a48c1406 https://doi.org/10.1097/mpg.0000000000000387

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April 11, 2014Journal of Pediatric Gastroenterology and Nutrition

Intestinal Expression of the Anti‐Inflammatory Interleukin‐1 Homologue IL‐37 in Pediatric Inflammatory Bowel Disease

View Full Paper

Ask AI

Bookmark

Authors

SWSimon WeidlichTumkur University ABAna‐Maria BulauLudwig-Maximilians-Universität München TSTobias SchwerdLMU Klinikum

Discussion

Member takes

Implication

Observational study reveals epithelial and lymphoid IL-37 expression correlates with inflammation severity in pediatric IBD, suggesting a regulatory role in chronic gut inflammation.

Key Points

To assess the intestinal expression, cellular localization, and cytokine correlations of the anti-inflammatory cytokine IL-37 in children with chronic inflammatory bowel disease.
Obtained endoscopic intestinal biopsies from pediatric participants, comprising 18 patients with Crohn disease, 14 with ulcerative colitis, and 11 healthy controls.
Evaluated IL-37 protein and mRNA expression via immunohistochemistry and real-time polymerase chain reaction, correlating findings with histological inflammation severity, clinical parameters, and levels of IL-18, IL-17, IL-8, and IL-10.
IL-37 protein localized to intestinal epithelial cells and submucosal lymphoid cells in healthy controls and IBD patients, with higher lymphoid expression positively correlating with histological inflammation severity scores.
Messenger RNA levels of IL-8, IL-17, and IL-10 were significantly elevated in Crohn disease and ulcerative colitis, whereas IL-37 and IL-18 mRNA levels were not significantly elevated compared to controls but showed a positive correlation with each other in Crohn disease.

Cite This Study

Weidlich et al. (2014) studied this question.

synapsesocial.com/papers/6a9864e604c78a31a48c1406 https://doi.org/10.1097/mpg.0000000000000387

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