Drug (Tremorine)-Induced Tremor in the Cat

Introduction A method of studying possible anatomical substrates involved in the production of a rest-type tremor has been provided by use of the drug Tremorine (1,4-dipyrrolidino-2-butyne)2in the cat. Reports dealing with an analysis of the tremor-producing properties of this compound have been primarily those of Everett et al.1These authors indicated that decerebration (presumably intercollicular) in the mouse, rat, and rabbit (cat, dog, and monkey not specifically indicated) and decerebellation in the dog failed to eliminate the tremor. In addition, spinalcord section prevented tremor below, but not above, the level of the section. In order to determine the amount of brain essential for the "specific" effect of this drug, cats were studied after transections at various levels between spinal cord and forebrain. The results and relevant correlations of this approach are herein described. Attention is particularly directed toward the following section on "Methods" because a clear concept