Key result
A lower triglyceride to high-density lipoprotein cholesterol ratio independently increased the risk of hemorrhagic transformation in patients with acute ischemic stroke attributable to large artery atherosclerosis (OR 0.53).
Why the study?
Does a low TG/HDL-C ratio predict hemorrhagic transformation in patients with acute ischemic stroke?
Cohort (n=1,981)
Yes
Does a low TG/HDL-C ratio predict hemorrhagic transformation in patients with acute ischemic stroke?
Odds Ratio: 0.53 (95% CI 0.2–0.93)
p-value: p=0.032
A lower TG/HDL-C ratio is independently associated with an increased risk of hemorrhagic transformation in patients with acute ischemic stroke attributable to large artery atherosclerosis.
May aid hemorrhagic transformation risk stratification in large artery atherosclerosis stroke; hypothesis-generating and requires prospective validation before clinical use.
=0.006) in patients with AIS attributable to large artery atherosclerosis (LAA), but not in those who suffered from cardioembolic stroke. After adjustment for covariates, a lower TG/HDL-C (OR=0.53, 95%CI=0.20-0.93) that was more than TG alone (OR=0.61, 95%CI=0.27-0.98) independently increased the risk of HT in LAA. Furthermore, our established nomogram indicated that lower TG/HDL-C was an indicator of HT. These findings were further validated in the test cohort of 558 patients with AIS attributable to LAA. In summary, a low level of TG/HDL-C is correlated with greater risk of HT after AIS attributable to LAA.
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Liu et al. (2019) conducted a cohort in Acute Ischemic Stroke (n=1,981). Low triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio vs. Higher TG/HDL-C ratio was evaluated on Hemorrhagic transformation (HT) after acute ischemic stroke (OR 0.53, 95% CI 0.20-0.93, p=0.032). A lower triglyceride to high-density lipoprotein cholesterol ratio independently increased the risk of hemorrhagic transformation in patients with acute ischemic stroke attributable to large artery atherosclerosis (OR 0.53).
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