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Synthesizes platelet roles in thrombosis for current management; leaves open targeted antiplatelet research in arterial disease.
IT has been known for many years that, when a blood vessel is damaged, platelet masses form in the lumen of this vessel and partially or totally occlude the flow of blood and hinder or prevent the escape of blood through any breach in the wall of that vessel. Furthermore, there is increasing awareness that platelet masses are important constituents of arterial thrombi. This ability of platelets to adhere to one another, which can be seen in shed blood when it is agitated as it is allowed to clot, is in fact difficult to prevent without elaborate precautions, has tended . . .
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A. A. Sharp (1965) studied this question.
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