January 1, 1993Open Access

Pharmacokinetic parameters and haemodynamic actions of midodrine in young volunteers

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Why the study?

Does midodrine alter pharmacokinetic and haemodynamic parameters in healthy volunteers and patients with postural hypotension?

Population

12 healthy male volunteers and 15 young patients with postural hypotension

Comparison

Midodrine vs Placebo and oxilofrine 20 mg intravenously

Design

RCT, Randomized cross-over design and randomized order, Double blind

Follow-up

Up to 24 hours

Authors

HGH. GrobeckerUniversity of Regensburg FKFrieder KeesUniversity of Regensburg

Discussion

Member takes

Implication

Supports midodrine for sympathotonic orthostatic hypotension; extends RCT evidence of its alpha-adrenergic hemodynamic efficacy.

Structured PICO

Does midodrine alter pharmacokinetic and haemodynamic parameters in healthy volunteers and patients with postural hypotension?

Population

12 healthy male volunteers (pharmacokinetic study) and 15 young patients with postural hypotension (pharmacodynamic study)

Intervention

Midodrine (2.5 mg intravenously, oral solution, or tablet for pharmacokinetics; 5 mg intravenously or increasing oral doses up to 15 mg for pharmacodynamics)

Comparator

Placebo and oxilofrine 20 mg intravenously

Outcome

Pharmacokinetic parameters (Cmax, t1/2, AUC) and haemodynamic actions (blood pressure, heart rate, echocardiographic parameters, circulating catecholamines)surrogate

Midodrine demonstrates rapid oral absorption and effective alpha-sympathomimetic hemodynamic effects, supporting its use in patients with sympathotonic orthostatic hypotension.

Limitations

Relatively small number of volunteers

Cite This Study

Grobecker et al. (1993) studied this question.

synapsesocial.com/papers/6a9865ad4e6c8dba1244e0b8 https://doi.org/10.5283/epub.26825

Topics

Echocardiography

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January 1, 1993Open Access

Pharmacokinetic parameters and haemodynamic actions of midodrine in young volunteers

View Full Paper

Ask AI

Bookmark

Why the study?

Does midodrine alter pharmacokinetic and haemodynamic parameters in healthy volunteers and patients with postural hypotension?

Population

12 healthy male volunteers and 15 young patients with postural hypotension

Comparison

Midodrine vs Placebo and oxilofrine 20 mg intravenously

Design

RCT, Randomized cross-over design and randomized order, Double blind

Follow-up

Up to 24 hours

Authors

HGH. GrobeckerUniversity of Regensburg FKFrieder KeesUniversity of Regensburg

Discussion

Member takes

Implication

Supports midodrine for sympathotonic orthostatic hypotension; extends RCT evidence of its alpha-adrenergic hemodynamic efficacy.

Structured PICO

Does midodrine alter pharmacokinetic and haemodynamic parameters in healthy volunteers and patients with postural hypotension?

Population

12 healthy male volunteers (pharmacokinetic study) and 15 young patients with postural hypotension (pharmacodynamic study)

Intervention

Midodrine (2.5 mg intravenously, oral solution, or tablet for pharmacokinetics; 5 mg intravenously or increasing oral doses up to 15 mg for pharmacodynamics)

Comparator

Placebo and oxilofrine 20 mg intravenously

Outcome

Pharmacokinetic parameters (Cmax, t1/2, AUC) and haemodynamic actions (blood pressure, heart rate, echocardiographic parameters, circulating catecholamines)surrogate

Midodrine demonstrates rapid oral absorption and effective alpha-sympathomimetic hemodynamic effects, supporting its use in patients with sympathotonic orthostatic hypotension.

Limitations

Relatively small number of volunteers

Cite This Study

Grobecker et al. (1993) studied this question.

synapsesocial.com/papers/6a9865ad4e6c8dba1244e0b8 https://doi.org/10.5283/epub.26825

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

Topics

Echocardiography

View Full Paper

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