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In the presence of the stroma-free hemolyzate of rat, rabbit, and human erythrocytes, GSSG has been shown to be reduced by G-6-P and TPN+, HDP and DPN+, or by chemically reduced TPNH and DPNH. Evidence has been presented that DPNH–GSSG reductase requires a cofactor for full activity.
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Francoeur et al. (1954) studied this question.
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