Key result
Tobacco use significantly increased the risk of target lesion revascularization (OR 11.71) in patients with coronary heart disease following stent placement over a 7-year follow-up.
Why the study?
Do poor daily lifestyle habits increase the risk of target lesion revascularization in patients with CHD following stent placement?
Cohort (n=129)
Single-blind
No
Do poor daily lifestyle habits increase the risk of target lesion revascularization in patients with CHD following stent placement?
Poor daily lifestyle habits, including tobacco use, heavy drinking, and dinner satiety, significantly increase the risk of target lesion revascularization in patients with CHD following stent placement.
Tobacco use was associated with higher TLR risk post-stenting; supports lifestyle-focused trials but should not yet change practice.
Limited data are available with regard to the impact of daily lifestyle choices in patients with coronary heart disease (CHD) who have undergone stent placement. Thus, the aim of the present study was to investigate the impact of daily lifestyle factors in patients with CHD following stent implantation. Between March 2005 and March 2006, 129 consecutive patients with CHD were admitted to Cangzhou Central Hospital at Hebei Medical University (Cangzhou, China). The patients underwent coronary stenting and participated in a 7‑year clinical follow‑up that analyzed the impact of their daily lifestyle choices on CHD following the stent placement. Rates of dinner satiety [95% confidence interval (CI), 1.121‑10.97, P=0.005], smoking (95% CI, 4.05‑34.90, P=2.01x10‑7) and heavy alcohol use (95% CI, 1.32‑11.05, P=0.006) were significantly higher in the repeated (re)‑revascularization group when compared with the non‑revascularization group. In addition, the exercise rate was significantly lower in the re‑revascularization group when compared with the non‑revascularization group (95% CI, 0.02‑0.65, P=0.005). However, no statistically significant differences were observed between the groups with regard to sleeping patterns (95% CI, 0.03‑0.71, P=0.270) or anxiety rates (P=0.289). A coronary angiography performed during re‑revascularization revealed in‑stent restenosis in 26% of the patients, stenoses at the entrance to or exit from the stent in 29% of the patients and new lesions in 19% of the patients. Furthermore, original lesions exhibited deterioration in 26% of the patients. The clinical endpoint was reached in 55% of the patients between 3 and 5 years of the follow‑up period. In conclusion, poor daily lifestyle habits can increase the in‑stent restenosis rate, accelerate the progression of the original lesion and promote the emergence of new lesions in patients with CHD following stent placement.
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Wan et al. (2015) conducted a cohort in Coronary heart disease (CHD) following stent implantation (n=129). Tobacco use vs. No tobacco use was evaluated on Target lesion revascularization (repeated PCI or CABG) (OR 11.71, 95% CI 3.95-34.71, p=<0.001). Tobacco use significantly increased the risk of target lesion revascularization (OR 11.71) in patients with coronary heart disease following stent placement over a 7-year follow-up.
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