Key result
Optimal cardiovascular health after percutaneous coronary intervention was associated with a reduced risk of revascularization compared to inadequate cardiovascular health (HR 0.83; 95% CI 0.73-0.94).
Why the study?
Whether optimal cardiovascular health metrics reduce the risk of cardiovascular events in secondary prevention is uncertain.
Do optimal lifestyle changes and cardiovascular health metrics reduce the risk of revascularization in patients who underwent percutaneous coronary intervention?
Cohort (n=17,099)
Do optimal lifestyle changes and cardiovascular health metrics reduce the risk of revascularization in patients who underwent percutaneous coronary intervention?
Hazard Ratio: 0.83 (95% CI 0.73–0.94)
Absolute Event Rate: 8% vs 10.6%
p-value: p=0.003
Achieving ideal cardiovascular health metrics (Life's Simple 7) after percutaneous coronary intervention is associated with a significantly lower risk of subsequent revascularization.
Lifestyle changes post-PCI were associated with lower revascularization; leaves open whether interventions improve secondary prevention.
Objective . Whether optimal cardiovascular health metrics may reduce the risk of cardiovascular events in secondary prevention is uncertain. The study was conducted to evaluate the influence of lifestyle changes on clinical outcomes among the subjects underwent percutaneous coronary intervention (PCI). Methods . The study group consists of 17,099 consecutive PCI patients. We recorded data on subject lifestyle behavior changes after their procedure. Patients were categorized as ideal, intermediate, or poor CV health according to a modified Life’s Simple 7 score (on body mass, smoking, physical activity, diet, cholesterol, blood pressure, and glucose). Multivariable COX regression was used to evaluate the association between CV health and revascularization event. We also tested the impact of cumulative cardiovascular health score on reoccurrence of cardiovascular event. Results . During a 3‐year median follow‐up, 1,583 revascularization events were identified. The observed revascularization rate was 8.0%, 9.3%, and 10.6% in the group of patients with optimal (a modified Life’s Simple 7 score of 11–14), average (score = 9 or 10), or inadequate (less or equal than 8) CV health, respectively. After multivariable analysis, the adjusted hazard ratios were 0.83 (95% CI: 0.73–0.94) and 0.89 (95% CI: 0.79–0.99) for patients with optimal and average lifestyle changes comparing with the inadequate tertile ( P for trend = 0.003). In addition, each unit increase in above metrics was associated with a decrease risk of revascularization (HR, 0.96; 95% confidence interval, 0.93–0.98; P < 0.001). Conclusion . Ideal CV health related to lower incidence of cardiovascular events, even after the percutaneous coronary intervention. Revascularization can be reduced by lifestyle changes. The cardiovascular health metrics could be extrapolated to secondary prevention and need for further validation.
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Wang et al. (2020) conducted a cohort in Percutaneous coronary intervention (PCI) (n=17,099). Optimal cardiovascular health (modified Life's Simple 7 score 11-14) vs. Inadequate cardiovascular health (score ≤8) was evaluated on Revascularization event (HR 0.83, 95% CI 0.73-0.94, p=0.003). Optimal cardiovascular health after percutaneous coronary intervention was associated with a reduced risk of revascularization compared to inadequate cardiovascular health (HR 0.83; 95% CI 0.73-0.94).
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