Key result
14,15-DHET relaxes bovine coronary arteries through activation of KCa channels, but is approximately fivefold less potent than 14,15-EET.
14,15-DHET relaxes coronary arteries via K(Ca) channel activation, though it is less potent than its precursor 14,15-EET, indicating that endothelial conversion of EETs to DHETs reduces vasodilator activity.
No takes yet. Share an insight, caveat, or question.
Should not change coronary vasodilator practice; leaves open whether EET-to-DHET conversion modulates human vascular tone.
Campbell et al. (2002) studied this question. 14,15-DHET vs. 14,15-EET was evaluated on Vascular relaxation and KCa channel activity. 14,15-DHET relaxes bovine coronary arteries through activation of KCa channels, but is approximately fivefold less potent than 14,15-EET.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: