Key result
Women undergoing coronary bypass surgery had a higher Charlson comorbidity index than men (5.2 vs 3.6) and different >5-year survival rates (58.8% vs 36.6%, p=0.04).
Why the study?
Does gender and comorbidity burden influence complications and outcomes of coronary bypass surgery in patients with ischemic heart disease?
Observational (n=127)
No
Does gender and comorbidity burden influence complications and outcomes of coronary bypass surgery in patients with ischemic heart disease?
Absolute Event Rate: 58.8% vs 36.6%
p-value: p=0.04
Women undergoing coronary bypass surgery have a higher comorbidity burden than men, which strongly correlates with an increased risk of perioperative complications.
Higher comorbidity in women post-CABG warrants targeted perioperative vigilance; leaves open whether gender modifies long-term survival independent of burden.
Aim. To study prevalence of cardiovascular, respiratory, urinary tract and gastrointestinal comorbidity for the improvement of prediction of complications and adverse outcomes in coronary bypass surgery in patients with coronary heart disease, incl. gender differences. Material and methods. We observed 127 patients (73,2% — males, 26,8% — females), operated for ischemic heart disease in Altai regional clinical hospital. Mean age at the moment of surgery was 58,9±6,3 y.o. Bypass operation was done as indicated, under on-pump conditions with pharmaco-cold cardioplegy. Results. Comorbidity index by Charlson (CIС) was 4,7 [4,1-5,3] points; in men — 3,6 [3,2-4,1], in women — 5,2 [4,7-5,6] (p5) у for women — 58,8% vs 36,6% (р=0,04). CIC correlated with the following operation complications: heart failure required inotropes for >5 days (r=0,73); perioperation myocardial infarction (r=0,71); acute disorder of brain circulation confirmed by computed tomography (r=0,56); heart rhythm disorders: atrial fibrillation, paroxysmal ventricular tachycardia (r=0,52); respiratory failure led to prolonged artificial ventilatory support >5 days. (r=0,48). Conclusion. CIC shows gender differences and is characterized by higher risk of adverse outcomes in women: survival 70 y.o., heart failure, diabetes, chronic kidney disease (≥III stage) and duration of on-pump period.
No takes yet. Share an insight, caveat, or question.
Klester et al. (2016) conducted an observational in Coronary heart disease (n=127). Female gender and higher Charlson comorbidity index vs. Male gender was evaluated on Survival >5 years (p=0.04). Women undergoing coronary bypass surgery had a higher Charlson comorbidity index than men (5.2 vs 3.6) and different >5-year survival rates (58.8% vs 36.6%, p=0.04).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: