Why the study?
Are electron transfer complex activities in platelet mitochondria altered in Parkinson's disease compared to controls and Parkinson-plus syndromes?
Population
79 subjects: 44 control subjects, 27 patients with idiopathic Parkinson's disease, and 8 patients with…
Design
Case-control
Follow-up
intervals of several months up to 1 year
Authors
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May distinguish idiopathic PD from Parkinson-plus syndromes via platelet assays; leaves open prospective validation before clinical adoption.
Are electron transfer complex activities in platelet mitochondria altered in Parkinson's disease compared to controls and Parkinson-plus syndromes?
Platelet mitochondrial complex I and IV activities are abnormal in idiopathic Parkinson's disease but normal in Parkinson-plus syndromes.
Benecke et al. (1993) studied this question.