Key result
Echinacoside significantly alleviated myocardial damage, cardiac dysfunction, and fibrosis in septic mice by upregulating SOD2 and decreasing the release of reactive oxygen species.
Why the study?
The study aimed to explore the beneficial effects of echinacoside against sepsis-induced myocardial damage and elucidate its potential mechanism.
Does Echinacoside prevent sepsis-induced myocardial damage in septic mice?
Does Echinacoside prevent sepsis-induced myocardial damage in septic mice?
Answers are grounded in this paper and cite their sources.
Echinacoside demonstrates cardioprotective effects in a murine model of sepsis by targeting SOD2 to reduce oxidative stress.
Echinacoside (ECH) is a prominent naturally occurring bioactive compound with effects of alleviating myocardial damage. We aimed to explore the beneficial effects of ECH against sepsis-induced myocardial damage and elucidate the potential mechanism. Echocardiography and Masson staining demonstrated that ECH alleviates cardiac function and fibrosis in the cecal ligation and puncture (CLP) model. Transcriptome profiling and network pharmacology analysis showed that there are 51 overlapping targets between sepsis-induced myocardial damage and ECH. Subsequently, chemical carcinogenesis-reactive oxygen species (ROS) were enriched in multiple targets. Wherein, SOD2 may be the potential target of ECH on sepsis-induced myocardial damage. Polymerase chain reaction results showed that ECH administration could markedly increase the expression of SOD2 and reduce the release of ROS. Combined with injecting the inhibitor of SOD2, the beneficial effect of ECH on mortality, cardiac function, and fibrosis was eliminated, and release of ROS was increased after inhibiting SOD2. ECH significantly alleviated myocardial damage in septic mice, and the therapeutic mechanism of ECH is achieved by upregulating SOD2 which decreased the release of ROS.
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Li et al. (2023) studied Sepsis-induced myocardial damage. Echinacoside (ECH) was evaluated on Myocardial damage, cardiac function, and fibrosis. Echinacoside significantly alleviated myocardial damage, cardiac dysfunction, and fibrosis in septic mice by upregulating SOD2 and decreasing the release of reactive oxygen species.
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