Key result
Elevated mouse hepatic betatrophin expression induced by S961 treatment did not increase human beta-cell replication in transplanted human islets, which remained completely unresponsive.
Why the study?
Does administration of insulin receptor antagonist S961 (to increase betatrophin) stimulate replication of transplanted human β-cells?
Population
Mice with transplanted human β-cells under the kidney capsule and endogenous mouse β-cells in the pancreas
Design
Preclinical
Authors
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Casts doubt on betatrophin's therapeutic potential for human diabetes; leaves open species-specific β-cell regeneration strategies.
Does administration of insulin receptor antagonist S961 (to increase betatrophin) stimulate replication of transplanted human β-cells?
Absolute Event Rate: 0.5% vs 0.5%
Betatrophin induction via S961 stimulates mouse but not human β-cell replication, casting doubt on its therapeutic potential for human diabetes.
Jiao et al. (2013) studied Diabetes (Beta-cell replication) (n=5). S961 (insulin receptor antagonist) vs. Vehicle (H2O) was evaluated on Human beta-cell replication rate (percentage of BrdU+/insulin+ cells). Elevated mouse hepatic betatrophin expression induced by S961 treatment did not increase human beta-cell replication in transplanted human islets, which remained completely unresponsive.
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