Why the study?
Does raised extracellular potassium attenuate the heart rate response to sympathetic nerve stimulation in isolated guinea-pig atria?
Does raised extracellular potassium attenuate the heart rate response to sympathetic nerve stimulation in isolated guinea-pig atria?
Extreme physiological levels of extracellular potassium attenuate the positive chronotropic response to cardiac sympathetic activation by decreasing the activation of the I(f) current, potentially protecting the myocardium from excessive noradrenaline.
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High extracellular K+ attenuates sympathetic chronotropy in guinea-pig atria; leaves open relevance to human hyperkalemia or HF.
Choate et al. (2001) studied this question.
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