A therosclerosis is a complex and chronic pathological state that adversely affects the structure of blood vessels. Vascular inflammation, endothelial damage, smooth muscle cell migration, foam cell accumulation, and lipid and cholesterol deposition contribute to different stages of plaque formation in large and medium-sized blood vessels. The consequential narrowing and stiffening of blood vessels restricts blood circulation and increases plaque thrombogenicity. Pathogenic causes that lead to these pathological changes in atherosclerosis have always been the center of attention, but we have not yet cleared the cloud on this issue.
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Rui Wang (2008) studied this question.
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