Cyclopolymerization of a bis-methacrylate monomer derived from trans-cyclohexanediol and 2-methacryloyloxyethyl isocyanate proceeded through 19-membered ring formation. The unusual large ring formation originated from the designed steric regulation by the cyclohexane ring and the hydrogen bonds. The RAFT polymerization employing cumyl dithiobenzoate attained controlled polymerization, which supported the quantitative cyclization.
No takes yet. Share an insight, caveat, or question.
Ochiai et al. (2008) studied this question.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: