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March 1, 2020Diabetes Metabolic Syndrome and ObesityOpen Access

The Effects of Synbiotic Supplementation on Glycemic Status, Lipid Profile, and Biomarkers of Oxidative Stress in Type 1 Diabetic Patients. A Placebo-Controlled, Double-Blind, Randomized Clinical Trial

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Authors

AJAhmad Zare JavidAhvaz Jundishapur University of Medical SciencesMAMajid AminzadehAhvaz Jundishapur University of Medical SciencesMHMohammad Hosein HaghighizadehAhvaz Jundishapur University of Medical Sciences

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Implication

Randomized double-blind trial demonstrates improved glycemic control and reduced inflammation in type 1 diabetes, highlighting the metabolic benefits of synbiotics.

Key Points

  • To evaluate the effects of synbiotic supplementation on glycemic status, lipid profile, and biomarkers of oxidative stress in patients with type 1 diabetes mellitus.
  • Double-blind, placebo-controlled randomized clinical trial in 50 patients with type 1 diabetes mellitus allocated to an intervention group (n = 25) or control group (n = 25).
  • Participants received 2 g per day of either synbiotic powder (Lactobacillus sporogenes GBI-30, maltodextrin, and fructooligosaccharide) or placebo for 8 weeks.
  • Fasting blood samples were analyzed before and after intervention for fasting blood glucose (FBG), insulin concentration, HbA1c, lipid profile, total antioxidant capacity (TAC), and hs-CRP.
  • Synbiotic supplementation led to significant decreases in mean serum HbA1c (p = 0.01) and hs-CRP (p = 0.004), alongside significantly greater reductions in mean changes of FBG (p = 0.03) and hs-CRP (p = 0.005) compared with control.
  • Mean serum insulin and TAC increased significantly post-intervention (p = 0.001), with a significant increase in mean TAC changes compared to the control group (p = 0.005).
  • No significant changes were detected in lipid profile parameters within the intervention group post-intervention (p ≥ 0.05).

Cite This Study

Javid et al. (2020) studied this question.

synapsesocial.com/papers/6a98749dbe2c00ad319778f4https://doi.org/10.2147/dmso.s238867
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Also Consider

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  1. 1Effects of Synbiotics on Inflammatory Markers in Patients With Type 2 Diabetes Mellitus2015 · 34 citations
  2. 2Intestinal dysbiosis and probiotic applications in autoimmune diseases2017 · 329 citations
  3. 3Validation of the Friedewald Formula in Patients with Metabolic Syndrome2014 · 203 citations
  4. 4Habitual dietary fibre intake influences gut microbiota response to an inulin-type fructan prebiotic: a randomised, double-blind, placebo-controlled, cross-over, human intervention study2018 · 273 citations