Key result
Type-II diabetes mellitus with preserved eGFR, with or without moderate albuminuria, was not associated with altered kidney elasticity compared to healthy controls (p>0.05).
Why the study?
Data are limited on whether early kidney damage caused by type-II diabetes mellitus alters renal elasticity.
Does type-II diabetes mellitus with or without moderate albuminuria alter renal elasticity measured by 2D shear wave elastography?
Cross-Sectional (n=57)
No
Does type-II diabetes mellitus with or without moderate albuminuria alter renal elasticity measured by 2D shear wave elastography?
Kidney elasticity measured by 2D shear wave elastography is not significantly altered in patients with type-II diabetes and preserved eGFR, regardless of moderate albuminuria.
Answers are grounded in this paper and cite their sources.
2D-SWV shows no renal elasticity difference in DM-II regardless of albuminuria; leaves open its utility for early diabetic nephropathy detection.
Objectives: Kidney damage caused by type-II diabetes mellitus (DM-II) can disturb renal elasticity. There is a paucity of data whether early kidney damage causes kidney stiffening. This comparative study aimed to assess kidney elasticity in patients with DM-II with or without moderate albuminuria using ultrasound based 2D shear wave velocity (2D-SWV). Methods: For this prospective single center study, a sample size of at least 32 was computed. Overall 57 cases (40 DM-II subjects with no chronic kidney disease and 17 age and sex matched healthy controls) were included. The DM-II subjects comprised moderate albuminuria (n=22) and no-albuminuria (n=18) subgroups. Bilateral renal parenchymal 2D-SWV values were separately measured from upper, mid and lower portions. Groups were compared with T test or Mann-Whitney-U test as appropriate. Inter-reader agreement was assessed by intra-class correlation coefficient (ICC). Results: The median age [55.5 (50-62) vs 55 (48.5-59.5) years, respectively, p=0.48] and gender rates [18 (45%) vs 10 (58.8%) females, respectively, p= 0.34] did not differ between DM-II and control groups. The average and individual portion 2D-SWV values were also similar (p>0.05 for all). The average 2D-SWV values were also similar between the albuminuria vs no-albuminuria subgroups. The interobserver agreement was good (ICC: 0.66, 95% CI: 0.19-0.88, p=0.006). Conclusion: The kidney elasticity does not seem to be disturbed in patients with diabetes and a preserved eGFR with or without moderate albuminuria.
No takes yet. Share an insight, caveat, or question.
Gündüz et al. (2021) conducted a cross-sectional in Type-II diabetes mellitus (n=57). Type-II diabetes mellitus vs. Healthy controls was evaluated on Average and individual portion 2D-SWV values (p=>0.05). Type-II diabetes mellitus with preserved eGFR, with or without moderate albuminuria, was not associated with altered kidney elasticity compared to healthy controls (p>0.05).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: