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Soft lenses: Reversible antibody–antigen cross-links at the surface of a hydrogel microlens allow focal tuning of the microlens in response to soluble antigens (see picture; PBS=phosphate-buffered saline) to form the basis of a label-free biosensor/bioassay technique, whose sensitivity can be tuned by controlling the number of cross-links required to effect a specific swelling response.
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Kim et al. (2006) studied this question.
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