Key result
Transfection with a miR-30b-5p inhibitor promoted myocardial cell proliferation and inhibited apoptosis (P<0.05) by regulating the Wnt/β-catenin signaling pathway.
Why the study?
The study aimed to screen differentially expressed miRNAs in heart tissues of rats with MI, explore the relationship between miR-30b-p and MI, and research its action mechanism.
Population
Rat MI models (3 MI and 3 sham rats) and derived myocardial cells
Comparison
miR-30b-5p inhibitor transfection vs miR-negative control transfection
Design
Preclinical animal and cellular experimental study
Authors
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miR-30b-5p inhibition may aid post-MI repair; hypothesis-generating in animal models and leaves open clinical translation.
p-value: p=<0.05
Inhibition of miR-30b-5p promotes myocardial cell proliferation and reduces apoptosis in a rat model of myocardial infarction via the Wnt/β-catenin signaling pathway.
Chi et al. (2021) studied Myocardial infarction (n=6). miR-30b-5p inhibitor vs. miR-negative control (NC) was evaluated on Myocardial cell proliferation and apoptosis (p=<0.05). Transfection with a miR-30b-5p inhibitor promoted myocardial cell proliferation and inhibited apoptosis (P<0.05) by regulating the Wnt/β-catenin signaling pathway.
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